- Observed skin regeneration effects of 3 times of collagen, 13 times of elastin, etc. - Published the paper on SCI journal, Experimental Dermatology   (PROSTEMICS=October 11, 2017) Prostemics (KOSDAQ 202690) announced that it studied the skin regeneration effect of exosomes derived from human adipose stem cells and published the results in the journal on October 11. The research result was published on the online version of Experimental Dermatology, an SCI journal, under the title of ‘Exosomes from human adipose derived stem cells (ASC-exo) promote proliferation and migration of skin fibroblasts’. An exosome is a nano-sized intercellular signal messenger, and is studied as the key of cell regeneration, metabolism, and diagnosis. ASC-exo is being actively studied in various areas because it encounters low immune system rejection while is expected to show high level of regeneration and cure effects. In this study, activation of ASC-exo in human dermal fibroblast led to the increase of collagen to 3 times, elastin to 13 times, and growth factors to 5 times. The study also demonstrated that the migration of human dermal fibroblast gets more active in cell medium with higher concentration of exosome, and thereby confirmed that the exosome plays a key role in regeneration effects of stem cells. An internal person of company said, “This is a leading study quantitatively confirming that the essential part of cell regeneration of stem cell lies in exosome. We are confident that we found a way to improve the effects of stem cell culture products”. The research team also said that it expects the expansion of the research to the exploration and development of medical materials. Prostemics has released the results of stem cell studies in more than 10 papers and the company’s products are getting the spotlight for more than 10 years in developed countries such as Japan and USA. In October, the company holds and international seminar with doctors from USA, Japan, China, Middle East, and Latin America, etc. in Kyoto, Japan, to explain and discuss the study results.